Intracellular Fluid Mechanics: Coupling Cytoplasmic Flow with Active Cytoskeletal Gel
نویسندگان
چکیده
The cell is a mechanical machine, and continuum mechanics of the fluid cytoplasm and the viscoelastic deforming cytoskeleton play key roles in cell physiology.We reviewmathematicalmodels of intracellular fluidmechanics, from cytoplasmic fluid flows, to the flow of a viscous active cytoskeletal gel, to models of two-phase poroviscous flows, to poroelastic models. We discuss application of these models to cell biological phenomena, such as organelle positioning, blebbing, and cell motility.We also discuss challenges of understanding fluid mechanics on the cellular scale.
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